WHAT IS PRP?
PRP (Platelet-Rich Plasma):
PRP application is based on the principle of obtaining plasma samples with high platelet concentration from whole blood.
What is Platelet (Thrombocyte) ?
Thrombocytes are blood cells that are involved in blood clotting, wound healing and tissue rejuvenation.
In case of injuries that cause bleeding, thrombocytes get activated releasing the proteins and growth factors (VEGF, IGF, FGF, PDGF, EGF, TGF-β) stored in their granules.
Growth factors provide wound healing and tissue rejuvenation by means of activation, proliferation and differentiation of stem cells.
PRP is blood plasma that has been enriched with platelets.
Action Mechanism of PRP Application
Erythrocytes (red blood cells) compose 93% of a healthy human blood whereas thrombocytes (platelets) compose 6% and leukocytes (white blood cells) 1%.
Those components forming blood can be separated from each other by means of centrifugation by the help of their differential molecular weights.
Action mechanism of PRP application is based on the principle of reversing the thrombocytes : erythrocytes ratio of whole blood. Compared to whole blood, platelet concentration becomes higher and erythrocyte concentration gets lower in the PRP fraction collected after centrifugation.
PRP is an autologous application: platelet-rich plasma collected from the patient’s own blood is again applied to the patient himself. Thus, there is no major risks of PRP application such as allergy and rejection.